IMMUNOBIOLOGY V 1 T lymphocytes producing IFN- and IL-17 are expanded in HIV-1–infected patients and respond to Candida albicans

نویسندگان

  • Daniela Fenoglio
  • Alessandro Poggi
  • Silvia Catellani
  • Florinda Battaglia
  • Alessandra Ferrera
  • Maurizio Setti
  • Giuseppe Murdaca
  • Maria Raffaella Zocchi
چکیده

1Centre of Excellence for Biological Sciences, University of Genoa, Genoa; 2Laboratory of Immunology, National Institute for Cancer Research, Genoa; 3Laboratory of Hematology, Department of Internal Medicine, 4Department of Internal Medicine, and 5Department of Semiotics, University of Genoa, Genoa; and 6Division of Immunology, Transplants, and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy

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منابع مشابه

V 1 T lymphocytes producing IFN- and IL-17 are expanded in HIV-1–infected patients and respond to Candida albicans

1Centre of Excellence for Biological Sciences, University of Genoa, Genoa; 2Laboratory of Immunology, National Institute for Cancer Research, Genoa; 3Laboratory of Hematology, Department of Internal Medicine, 4Department of Internal Medicine, and 5Department of Semiotics, University of Genoa, Genoa; and 6Division of Immunology, Transplants, and Infectious Diseases, San Raffaele Scientific Insti...

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Candida albicans stimulates IL-23 release by human dendritic cells and downstream IL-17 secretion by Vδ1 T cells.

γδ T cells expressing the Vδ1 TCR are expanded in patients with HIV infection. We show in this article that circulating Vδ1 T cell numbers are particularly high in patients with HIV and candidiasis, and that these cells expand and produce IL-17 in response to Candida albicans in vitro. Although C. albicans could directly stimulate IL-17 production by a subset of Vδ1 T cells, fungus-treated dend...

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CD8+ T Lymphocyte Subsets in Bladder Tumor Draining Lymph Nodes

Background: Cytotoxic CD8+ T cells, as essential parts of the adaptive immune system, play pivotal roles in anti-tumor immune responses. It is well documented that cytokine expression profiles and activation status of these cells during anti-tumor immune responses affect the outcome of host-tumor interaction. Objective: To investigate the percentages of CD8+ lymphocytes and their subsets in...

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Sequential Dysfunction and Progressive Depletion of Candida albicans-Specific CD4 T Cell Response in HIV-1 Infection

Loss of immune control over opportunistic infections can occur at different stages of HIV-1 (HIV) disease, among which mucosal candidiasis caused by the fungal pathogen Candida albicans (C. albicans) is one of the early and common manifestations in HIV-infected human subjects. The underlying immunological basis is not well defined. We have previously shown that compared to cytomegalovirus (CMV)...

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IL-17 and IL-4 Producing CD8+ T Cells in Tumor Draining Lymph Nodes of Breast Cancer Patients: Positive Association with Tumor Progression

Background: CD8+ cytotoxic T lymphocytes have been recently divided based on their cytokine expression profile. Objective: To evaluate the percentages of CD8+ lymphocytes and their effector subsets including Tc1, Tc2 and Tc17 in the tumor draining lymph nodes (TDLNs) of patients with breast cancer. Methods: Single cell suspensions were obtained from TDLNs of 42 patients with breast cancer. Stai...

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تاریخ انتشار 2009